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Welcome to the 2023 15th World Congress of the International Society for Immunology of Reproduction. The 2023 ISIR Word Congress will be held September 14th to 17th at the University Medical Center Hamburg-Eppendorf (Erika Haus), Hamburg, Germany. The primary goal of the 15th World Congress of the International Society for Immunology of Reproduction is to provide a stimulating and lively forum for presentation and discussion of the latest advances in clinical reproductive immunology, from primary pregnancy disorders and their impact on Maternal and Child Health to molecular pathogenesis and novel therapeutic approaches.