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List of contacts

Do you have any questions about ZB MED`s services or the range of literature we offer? Or maybe you need some tips on how to run searches in LIVIVO?

Phone: +49 (0)221 478-5685

Cologne Site

Medicine and Health

ZB MED – Information Centre for Life Sciences
Gleueler Straße 60
50931 Cologne (Köln)

Bonn Site

Nutritional, Environmental and Agricultural Sciences

ZB MED – Information Centre for Life Sciences
Friedrich-Hirzebruch-Allee 4
53115 Bonn




An infrastructure and research centre for data and information in the life sciences.

Life sciences research needs a solid infrastructure.

ZB MED carries out the applied research required to achieve this.


A computational tool for Grad-seq data analysis

RNA-RNA, RNA-protein and protein-protein interactions play an important role in post-transcriptional gene regulation in all living species. A global map of such interactions is an important step towards understanding the regulatory networks of an organism in more holistic terms. Grad-seq is a high-throughput profiling approach for the organism-wide detection of these interactions in which molecular complexes are separated in a gradient by shape and size. The Grad-seq approach offers a way to study the role of different RNA and protein components in various macromolecular assemblies by analyzing fractions of a glycerol gradient with high-throughput sequencing approaches and mass spectrometry. Developed in the Python programming language, GRADitude is a modular tool that performs all the steps required to translate sequencing and mass spectrometry data into a list of potential molecular complexes. It offers a wide range of visualization options that make it easier for users to gain a deeper understanding of the data.

ZB MED’s role in the project

ZB MED is developing GRADitude in close collaboration with experimental partners. Its goal is to facilitate the analysis of Grad-seq data.