Christine Desel

SFB877 / Biochemisches Institut

Christian Albrechts Universität

Olshausenstr. 40

D- 24098 Kiel

Proteases constitute 1%–5% of eukaryotic genes and the human genome encodes 566 predicted proteolytic enzymes. The functions of proteases are essential in many physiological processes, including development, blood coagulation, and cell death, as well as many pathophysiologic events such as inflammation, cancer and infectious diseases. The general aim of the CRC 877 is to obtain a profound understanding of proteolytic processes in cellular regulation and signaling and to define the involvement of such processes in human pathophysiology. The process of proteolysis is, in contrast to other posttranslational modifications such as protein phosphorylation, protein lipidation or protein methylation, completely irreversible. Therefore – at least theoretically – it might represent an entirely different and presumably higher level of regulation than the other mentioned protein modifications.

The doctoral students of the Integrated Research Training Group (IRTG)in the CRC 877 in Kiel invite you to come to our IRTG Symposium entitled "Proteolysis and Pathophysiology"

Topics of the Symposium:

Proteases at the Plasma Membrane

Structure, Mechanism & Function

Intracellular Proteolysis: From Cell Biology to Disease

Innovative Tools: Chromobodies & Proteomics